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Lactose intolerance: it also depends on genetics


What is the cause of the onset of the symptoms, and what may be the causes of the development of lactose intolerance? We asked Dr. Marianne Polgárr pediatrician, gastroenterologist, head doctor of the Buda Allergy Center.

Lactose intolerance: it also depends on genetics

More and more lactose-free products are on the shelves of stores: packaged milk, cheese, and other dairy products advertise that you can also consume the particular gift you have previously complained of in the lactose content. What depends on who develops lactose intolerance?

There are two common types of lactose intolerance

Abdominal stomach, bloating, stomachs, diarrhea - lactose intolerance, also known as milk sugar sensitivity. Lactic sensitivity can be fatal, it is called secondary (secondary) because it is caused by some disease in the future. However, there may be a genetically determined eventual alteration. Primary (primary) lactose intolerance is not prevented by disease as age progresses, usually develops above the age of 12 years it tends to occur in one-on-one.

Lactose intolerance: more and more people are asking for genetic testing

Recently, there has been a marked increase in interest in genetic testing for lactose sensitivity in infants and toddlers - reported on experience dr. Polgár Marianne, who was awarded the Award of the Doctor of Allergy by the Buda Allergy Center last year based on patient feedback. Parents are basically good at tracking, because at this age they have a history of abdominal complaints, abdominal cramps, some kind of foodiness, allergy or lactose йrzйkenysйg However, if lactose intolerance is the cause of the complaints, then in the background infants and young children are not due to genetic disorder but to some form of lactic dysfunction caused by the disease. Genetic testing can only be done over a certain age.

Occurs in early childhood: secondary to lactic malabsorption

In infants and toddlers, we have secondary, or secondary, lactic malabsorption, but this pattern can develop at any age. The reason for the breakdown of milk sugar is that the lactase enzyme, which is also called lactose, is found on the surface of small fleas, and is a disease that causes , the enzyme may function with reduced function. This form can also occur in infancy, in which case consuming too much milk sugar can cause temporary absorption problems. This is also called lactic malabsorption, which is eliminated by the transient state and regeneration of the pancreas.

Older Children: Adult Lactose Intolerance

Primary lactose intolerance occurs most often in the age of 10 years, but usually only in adulthood. Functioning of lactose-deficient enzyme genetically determined. As one progresses with age, without any eventuality, the enzyme's inhibition of function is lifted, thereby largely diminishing or eliminating lactose digestion. For some people, this primary lactose intolerance (China, Africa) affects more than 90% of the population, 27% in Hungary can be the number of lactose intolerances.

What are the Symptoms of Lactose Absorption?

Symptoms may be similar in infancy and adulthood, but the degree of severity depends on the level of enzyme activity (the less lactose is produced by the lactose digestion, the more food is consumed and the amount of milk you lose). In the intestines, he excreted milk sugar that was undigested. Milk sugar decomposes in the colon by gassing, which can cause bloating, abdominal cramps, bloating, abdominal pain, nausea, bowel movement, headache.

Examination: milk sugar sensitivity depends on type

Examination of the secondary and primary forms of lactose intolerance is possible by measuring the amount of gas produced from the thickened unabsorbed lactose. This is done by measuring the hydrogen ion from the exhaled air (H2 test). This can be measured after ingestion of 2g / kg bodyweight milk sugar, with appropriate formulations. There is no age limit for testing.

Genetic Test for Lactose Intolerance: Recommended for ages 12 and up

The primary test for measuring lactose intolerance is the genetic test, the lactase gene test, which tells you what genotype you are. The genetic status of the individual indicates whether he or she will become lactose intolerant throughout his or her life, whether homo- or heterozygous. Parent genotyping can determine whether the lactase enzyme gene in each individual is "switched off" after lactation, and the level of lactase enzyme is reduced. The rate of decrease is variable, with symptoms occurring when the enzyme level drops below the level required to increase the amount of milk sugar in the diet.This test is carried out in infants younger than 5 years of age. cannot be rewrittenBecause infants and toddlers are genetically capable of milk sugar reduction at all ages, it also allows breast milk to be consumed. The ability to degrade can be reduced from the age of 4-5 years, but genetic testing is only recommended over the age of 12, as it does not reflect the currently existing ability to degrade lactose.
  • Milk allergy or lactic acid?
  • Dietary allergy